概述

  • 产品名称Anti-POLR3B抗体
    参阅全部 POLR3B 一抗
  • 描述
    兔多克隆抗体to POLR3B
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus (Ornithorhynchus anatinus), Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 1083-1133 of Human POLR3B (NP_060552.3).

  • 阳性对照
    • Human Breast Carcinoma, Hodgkins Lymphoma and Testicular Seminoma tissues.

性能

应用

Our Abpromise guarantee covers the use of ab114967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.

靶标

  • 功能DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
  • 序列相似性Belongs to the RNA polymerase beta chain family.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C128 antibody
    • DNA directed RNA polymerase III 127.6 kDa polypeptide antibody
    • DNA directed RNA polymerase III subunit B antibody
    • DNA-directed RNA polymerase III 127.6 kDa polypeptide antibody
    • DNA-directed RNA polymerase III subunit B antibody
    • DNA-directed RNA polymerase III subunit RPC2 antibody
    • FLJ10388 antibody
    • polr3b antibody
    • Polymerase (RNA) III (DNA directed) polypeptide B antibody
    • RNA polymerase III subunit C2 antibody
    • RNA polymerase III subunit RPC2 antibody
    • RPC2 antibody
    • RPC2_HUMAN antibody
    see all

Anti-POLR3B antibody 图像

  • ab114967 at 1/250 dilution staining POLR3B in Formalin-fixed, Paraffin-embedded Human Hodgkin's Lymphoma tissue by Immunohistochemistry.
    Detection: DAB staining.
  • ab114967 at 1/500 dilution staining POLR3B in Formalin-fixed, Paraffin-embedded Human Breast Carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

Anti-POLR3B antibody (ab114967)参考文献

ab114967 has not yet been referenced specifically in any publications.

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