Anti-Polo like kinase kinase (phospho S482 + S486 + S490)抗体(ab30565)

概述

  • 产品名称Anti-Polo like kinase kinase (phospho S482 + S486 + S490)抗体
  • 描述
    兔多克隆抗体to Polo like kinase kinase (phospho S482 + S486 + S490)
  • 特异性Specific for the PLKK protein phosphorylated at serines 482, 486 and 490.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Xenopus laevis
  • 免疫原

    Phosphopeptide corresponding to amino acid residues surrounding the phosphorylation sites Ser 482,486 and 490 of Xenopus polo-like kinase kinase (PLKK).

  • 阳性对照
    • Xenopus oocyte lysate.

性能

应用

Our Abpromise guarantee covers the use of ab30565 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 120 kDa (predicted molecular weight: 112 kDa).

靶标

  • 相关性Polo-like kinase (PLK) plays an important role in cell cycle regulation. It is required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a polo-like kinase kinase (PLKK) that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.
  • 细胞定位Nuclear
  • 别名
    • Polo like kinase kinase 1 antibody
    • Serine/threonine kinase 10 antibody
    • stk10 a antibody
    • xPlkk1 antibody

Anti-Polo like kinase kinase (phospho S482 + S486 + S490) antibody (ab30565)参考文献

ab30565 has not yet been referenced specifically in any publications.

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