Anti-Poliovirus Receptor抗体[D171] (Biotin) (ab79434)

概述

  • 产品名称Anti-Poliovirus Receptor抗体[D171] (Biotin)
    参阅全部 Poliovirus Receptor 一抗
  • 描述
    小鼠单克隆抗体[D171] to Poliovirus Receptor (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: Flow Cyt, ICC/IFmore details
    不适用于: WB
  • 种属反应性
    与反应: Human, Monkey
    不与反应: Mouse, Rat, Rabbit, Hamster, Dog, Pig
  • 免疫原

    Tissue/ cell preparation (Human) - HeLa cells

  • 表位Amino acids 35-50
  • 阳性对照
    • HeLa, SV 80, HEp2, RD, A431, HL60, U937, Monkey Vero, GMK, or TC7 cells.
  • 常规说明


    This antibody protects HeLa cells against the cytopathic effect of all three poliovirus serotypes. Intact Ig or Fab fragment prevents binding of 35S-labeled poliovirus to HeLa cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.2% BSA, 10mM PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Purified from ascites fluid
  • Primary antibody说明This antibody protects HeLa cells against the cytopathic effect of all three poliovirus serotypes. Intact Ig or Fab fragment prevents binding of 35S-labeled poliovirus to HeLa cells.
  • 克隆单克隆
  • 克隆编号D171
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab79434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration. ab18434-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
    • 序列相似性Belongs to the nectin family.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 细胞定位Secreted and Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD155 antibody
      • CD155 antigen antibody
      • FLJ25946 antibody
      • HVED antibody
      • mE4 antibody
      • NECL 5 antibody
      • Necl-5 antibody
      • Necl5 antibody
      • Nectin like 5 antibody
      • Nectin like protein 5 antibody
      • Nectin-like protein 5 antibody
      • Ortholog of mouse Tage4 antibody
      • Poliovirus receptor antibody
      • PVR antibody
      • PVR_HUMAN antibody
      • PVS antibody
      • Taa1 antibody
      • Tage 4 antibody
      • TAGE4 antibody
      see all

    Anti-Poliovirus Receptor antibody [D171] (Biotin) (ab79434)参考文献

    ab79434 has not yet been referenced specifically in any publications.

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