Anti-Poliovirus Receptor/PVR抗体(ab103630)
Key features and details
- Rabbit polyclonal to Poliovirus Receptor/PVR
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Poliovirus Receptor/PVR抗体
参阅全部 Poliovirus Receptor/PVR 一抗 -
描述
兔多克隆抗体to Poliovirus Receptor/PVR -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Recombinant full length protein within Human Poliovirus Receptor/PVR aa 1-450. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: NP_006496.2 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab103630于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
1/500 - 1/1000. Predicted molecular weight: 45 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 45 kDa. |
靶标
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功能
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. -
序列相似性
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 5817 Human
- Entrez Gene: 52118 Mouse
- Omim: 173850 Human
- SwissProt: P15151 Human
- SwissProt: Q91WP1 Mouse
- Unigene: 171844 Human
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别名
- CD155 antibody
- CD155 antigen antibody
- FLJ25946 antibody
see all
图片
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Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution + Mouse stomach tissue lysate at 50 µg
Predicted band size: 45 kDa -
All lanes : Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution
Lane 1 : Poliovirus Receptor/PVR transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 45 kDa
实验方案
数据表及文件
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Datasheet download
文献 (4)
ab103630 被引用在 4 文献中.
- Zheng Q et al. CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer. Cancer Sci 111:383-394 (2020). PubMed: 31830330
- Duan X et al. Expression of TIGIT/CD155 and correlations with clinical pathological features in human hepatocellular carcinoma. Mol Med Rep 20:3773-3781 (2019). PubMed: 31485637
- Zheng Q et al. CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells. J Cell Mol Med 22:131-140 (2018). PubMed: 28816021
- Gao J et al. CD155 downregulation synergizes with adriamycin to induce breast cancer cell apoptosis. Apoptosis 23:512-520 (2018). PubMed: 30039180