概述

  • 产品名称Anti-POLG2抗体
    参阅全部 POLG2 一抗
  • 描述
    兔多克隆抗体to POLG2
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide selected from the C-terminal region of human POLG2 conjugated to KLH.

  • 阳性对照
    • K562 cell line lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab82860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).
ELISA 1/1000.

靶标

  • 功能Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
  • 疾病相关Defects in POLG2 are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4) [MIM:610131]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DNA directed DNA polymerase gamma 2 antibody
    • DNA polymerase gamma accessory 55 kDa subunit antibody
    • DNA polymerase subunit gamma 2, mitochondrial antibody
    • DNA polymerase subunit gamma-2 antibody
    • DPOG2_HUMAN antibody
    • HP55 antibody
    • mitochondrial antibody
    • Mitochondrial DNA polymerase accessory subunit antibody
    • Mitochondrial DNA polymerase subunit gamma 2 antibody
    • Mitochondrial polymerase gamma 2 antibody
    • MtPolB antibody
    • OTTMUSP00000003758 antibody
    • p55 antibody
    • PEOA4 antibody
    • POLB antibody
    • PolG beta antibody
    • PolG-beta antibody
    • POLG2 antibody
    • POLGB antibody
    • Polymerase (DNA directed), gamma 2, accessory subunit antibody
    • Polymerase, gamma 2 antibody
    • RP23-247J12.3 antibody
    see all

Anti-POLG2 antibody 图像

  • Anti-POLG2 antibody (ab82860) at 1/50 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 55 kDa
    Observed band size : 55 kDa
    Additional bands at : 100 kDa,37 kDa. We are unsure as to the identity of these extra bands.

Anti-POLG2 antibody (ab82860)参考文献

ab82860 has not yet been referenced specifically in any publications.

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