Anti-POLG2抗体(ab201100)
Key features and details
- Rabbit polyclonal to POLG2
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-POLG2抗体 -
描述
兔多克隆抗体to POLG2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide corresponding to Human POLG2.
Database link: Q9UHN1 -
阳性对照
- HeLa, HepG2, H9C2 and SP20 whole cell lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.05% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab201100 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab201100于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 55 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 55 kDa. |
靶标
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功能
Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA. -
疾病相关
Defects in POLG2 are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4) [MIM:610131]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. -
细胞定位
Mitochondrion. - Information by UniProt
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数据库链接
- Entrez Gene: 11232 Human
- Entrez Gene: 50776 Mouse
- Entrez Gene: 303612 Rat
- Omim: 604983 Human
- SwissProt: Q9UHN1 Human
- SwissProt: Q9QZM2 Mouse
- Unigene: 437009 Human
- Unigene: 859 Mouse
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别名
- DNA directed DNA polymerase gamma 2 antibody
- DNA polymerase gamma accessory 55 kDa subunit antibody
- DNA polymerase subunit gamma 2, mitochondrial antibody
see all
图片
数据表及文件
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Datasheet download
文献 (0)
ab201100 尚未被引用在任何文献中。