概述

  • 产品名称Anti-POGZ抗体
    参阅全部 POGZ 一抗
  • 描述
    兔多克隆抗体to POGZ
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residues 1360 and 1410 of Human POGZ (NP_055915.2).

  • 阳性对照
    • Human breast carcinoma, colon carcinoma, non-small cell lung cancer, ovarian carcinoma, prostate carcinoma, stomach adenocarcinoma and testicular seminoma tissue.
      Mouse colon carcinoma CT26, hybridoma tumor, renal cell carcinoma and teratoma tissue.
  • 常规说明Shelf Life: 1 year from date of receipt

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituents: 99% Tris buffered saline, 0.1% BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Affinity purified using an epitope specific to POGZ immobilized on solid support
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab124659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.
  • 序列相似性Contains 9 C2H2-type zinc fingers.
    Contains 1 DDE domain.
    Contains 1 HTH CENPB-type DNA-binding domain.
  • 细胞定位Nucleus. Chromosome. Cytoplasm. According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KIAA0461 antibody
    • MGC71543 antibody
    • Pogo transposable element with ZNF domain antibody
    • POGZ antibody
    • POGZ_HUMAN antibody
    • putative protein product of Nbla00003 antibody
    • SUHW5 antibody
    • suppressor of hairy wing homolog antibody
    • Suppressor of hairy wing homolog 5 antibody
    • Zinc finger protein 280E antibody
    • Zinc finger protein 635 antibody
    • ZNF280E antibody
    • ZNF635 antibody
    • ZNF635M antibody
    see all

Anti-POGZ antibody 图像

  • ab124659, at 1/250 dilution, staining POGZ in Formalin-fixed Paraffin-embedded, Human breast carcinoma tissue by Immunohistochemistry. Detection by DAB staining.
  • ab124659, at 1/250 dilution, staining POGZ in Formalin-fixed Paraffin-embedded, Mouse hybridoma tumor tissue by Immunohistochemistry. Detection by DAB staining.

Anti-POGZ antibody (ab124659)参考文献

ab124659 has not yet been referenced specifically in any publications.

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