Anti-Podoplanin / gp36抗体[8.1.1] (ab92319)


  • 产品名称Anti-Podoplanin / gp36抗体[8.1.1]
    参阅全部 Podoplanin / gp36 一抗
  • 描述
    叙利亚仓鼠单克隆抗体[8.1.1] to Podoplanin / gp36
  • 经测试应用适用于: IHC-Fr, WB, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Tissue/ cell preparation (mouse): Thymic epithelial cell line.



Our Abpromise guarantee covers the use of ab92319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IHC-Fr: Use at a concentration of 0.5 - 1 µg/ml.
    IP: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 25 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
    • 组织特异性Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
    • 序列相似性Belongs to the podoplanin family.
    • 翻译后修饰Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
      The N-terminus is blocked.
    • 细胞定位Membrane. Cell projection > filopodium membrane. Cell projection > lamellipodium membrane. Cell projection > microvillus membrane. Cell projection > ruffle membrane. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Aggrus antibody
      • Glycoprotein 36 KD antibody
      • Glycoprotein 36 antibody
      • gp 36 antibody
      • GP 38 antibody
      • GP 40 antibody
      • gp36 antibody
      • GP38 antibody
      • GP40 antibody
      • HT1A 1 antibody
      • HT1A1 antibody
      • hT1alpha 1 antibody
      • hT1alpha 2 antibody
      • hT1alpha1 antibody
      • hT1alpha2 antibody
      • Lung type I cell membrane associated glycoprotein antibody
      • Lung type I cell membrane associated glycoprotein isoform a antibody
      • Lung type I cell membrane associated glycoprotein T1A 2 antibody
      • OTS 8 antibody
      • OTS8 antibody
      • OTTHUMP00000009640 antibody
      • OTTHUMP00000044504 antibody
      • PA2.26 antibody
      • PA2.26 antigen antibody
      • Pdpn antibody
      • PDPN_HUMAN antibody
      • Podoplanin antibody
      • PSEC0003 antibody
      • PSEC0025 antibody
      • T1 alpha antibody
      • T1 ALPHA GENE antibody
      • T1-alpha antibody
      • T1A 2 antibody
      • T1A antibody
      • TI1A antibody
      • TIA 2 antibody
      • TIA2 antibody
      see all

    Anti-Podoplanin / gp36 antibody [8.1.1] 图像

    • Frozen section (7.5 micron) of murine kidney were incubated with ab92319 antibody at 1ug/ml and detected with an Alexa Fluor®488-conjugated Goat anti-hamster IgG polyclonal used at 1:1000 dilution. Exposure time 500 ms.

    Anti-Podoplanin / gp36 antibody [8.1.1] (ab92319)参考文献

    This product has been referenced in:
    • Farr A  et al. Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus. J Histochem Cytochem 40:651-64 (1992). Read more (PubMed: 1374092) »
    • Farr AG  et al. Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J Exp Med 176:1477-82 (1992). Read more (PubMed: 1402691) »

    See all 2 Publications for this product

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