概述

  • 产品名称Anti-PNPO抗体
    参阅全部 PNPO 一抗
  • 描述
    兔多克隆抗体to PNPO
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 35-84 (PMRKSYRGDR EAFEETHLTS LDPVKQFAAW FEEAVQCPDI GEANAMCLAT) of Human PNPO, NP_060599.

  • 阳性对照
    • Fetal muscle lysate

性能

应用

Our Abpromise guarantee covers the use of ab83875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 30 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
  • 通路Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.
    Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.
  • 疾病相关Defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:610090]; also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine.
  • 序列相似性Belongs to the pyridoxamine 5'-phosphate oxidase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EC 1.4.3.5 antibody
    • FLJ10535 antibody
    • PDXPO antibody
    • PNPO antibody
    • PNPO_HUMAN antibody
    • Pyridoxal 5' phosphate synthase antibody
    • pyridoxamine 5' phosphate oxidase antibody
    • Pyridoxamine phosphate oxidase antibody
    • Pyridoxamine-phosphate oxidase antibody
    • pyridoxine 5' phosphate oxidase antibody
    • Pyridoxine-5'-phosphate oxidase antibody
    see all

Anti-PNPO antibody 图像

  • Anti-PNPO antibody (ab83875) at 1 µg/ml + fetal muscle lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 30 kDa
    Observed band size : 30 kDa

Anti-PNPO antibody (ab83875)参考文献

ab83875 has not yet been referenced specifically in any publications.

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