产品名称 Anti-PNPO抗体 参阅全部 PNPO 一抗
WB more details
PNPO (NP_060599.1, 1 a.a. ~ 261 a.a) full-length human protein.
transfected 293T cell lysate
存放说明 Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
存储溶液 Preservative: None
Constituents: Whole serum
纯度 Whole antiserum
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 27 kDa (predicted molecular weight: 30 kDa).
功能 Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
通路 Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.
疾病相关 Defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:610090]; also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine.
序列相似性 Belongs to the pyridoxamine 5'-phosphate oxidase family.
Information by UniProt
EC 184.108.40.206 antibody
Anti-PNPO antibody 图像
Western blot - PNPO antibody (ab72647)
All lanes : Anti-PNPO antibody (ab72647) at 1/500 dilution Lane 1 : PNPO-transfected 293T cell line lysate Lane 2 : Non-transfected 293T cell line lysate Secondary HRP-conjugated goat anti-mouse IgG at 1/2500 dilution Predicted band size : 30 kDa Observed band size : 27 kDa ( why is the actual band size different from the predicted?)
Anti-PNPO antibody (ab72647)参考文献
has not yet been referenced specifically in any publications.
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