Anti-PNPO抗体[1H9] (ab119395)

概述

  • 产品名称Anti-PNPO抗体[1H9]
    参阅全部 PNPO 一抗
  • 描述
    小鼠单克隆抗体[1H9] to PNPO
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein of human PNPO produced in HEK293T cells (NP_060599).

  • 阳性对照
    • HEK293T cells transfected with PNPO, Human breast, Human Kidney, Carcinoma of Human liver, and Human thyroid tissues
  • 常规说明Dilute in PBS (pH7.3) before use.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab119395 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 30 kDa.
IHC-P 1/150.

靶标

  • 功能Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
  • 通路Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.
    Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.
  • 疾病相关Defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:610090]; also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine.
  • 序列相似性Belongs to the pyridoxamine 5'-phosphate oxidase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EC 1.4.3.5 antibody
    • FLJ10535 antibody
    • PDXPO antibody
    • PNPO antibody
    • PNPO_HUMAN antibody
    • Pyridoxal 5' phosphate synthase antibody
    • pyridoxamine 5' phosphate oxidase antibody
    • Pyridoxamine phosphate oxidase antibody
    • Pyridoxamine-phosphate oxidase antibody
    • pyridoxine 5' phosphate oxidase antibody
    • Pyridoxine-5'-phosphate oxidase antibody
    see all

Anti-PNPO antibody [1H9] 图像

  • All lanes : Anti-PNPO antibody [1H9] (ab119395) at 1/500 dilution

    Lane 1 : HEK293T cell lysate transfected with the pCMV6-ENTRY control
    Lane 2 : HEK293T cell lysate transfected with the pCMV6-ENTRY PNPO

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 30 kDa
    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC200133)
  • Immunohistochemical staining of paraffin-embedded Human breast tissue using ab119395 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Human Kidney tissue using ab119395 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using ab119395 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Human thyroid tissue using ab119395 at a dilution of 1/150.

Anti-PNPO antibody [1H9] (ab119395)参考文献

ab119395 has not yet been referenced specifically in any publications.

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