概述

  • 产品名称Anti-PNPO抗体[14]
    参阅全部 PNPO 一抗
  • 描述
    小鼠单克隆抗体[14] to PNPO
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog
  • 免疫原

    Recombinant fragment, corresponding to amino acids 41-261 of Human PNPO expressed in E.coli.

  • 阳性对照
    • HepG2 whole cell lysate
  • 常规说明Antibody may be stored at 2oC to 8oC for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody. Affinity = 3.84×109

性能

应用

Our Abpromise guarantee covers the use of ab106199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 30 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
  • 通路Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.
    Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.
  • 疾病相关Defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:610090]; also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine.
  • 序列相似性Belongs to the pyridoxamine 5'-phosphate oxidase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EC 1.4.3.5 antibody
    • FLJ10535 antibody
    • PDXPO antibody
    • PNPO antibody
    • PNPO_HUMAN antibody
    • Pyridoxal 5' phosphate synthase antibody
    • pyridoxamine 5' phosphate oxidase antibody
    • Pyridoxamine phosphate oxidase antibody
    • Pyridoxamine-phosphate oxidase antibody
    • pyridoxine 5' phosphate oxidase antibody
    • Pyridoxine-5'-phosphate oxidase antibody
    see all

Anti-PNPO antibody [14] 图像

  • Anti-PNPO antibody [14] (ab106199) at 1/1000 dilution + HepG2 whole cell lysate

    Predicted band size : 30 kDa

Anti-PNPO antibody [14] (ab106199)参考文献

ab106199 has not yet been referenced specifically in any publications.

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