概述

  • 产品名称Anti-PNK抗体
    参阅全部 PNK 一抗
  • 描述
    兔多克隆抗体to PNK
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 100-150 of Human PNK (SwissProt Q96T60).

  • 阳性对照
    • Human ovarian carcinoma

性能

应用

Our Abpromise guarantee covers the use of ab84374 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Antigen exposure is recommended.
    Antigen exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Plays an important function in DNA repair following ionizing radiation or oxidative damage.
    • 组织特异性Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193).
    • 疾病相关Defects in PNKP are the cause of microcephaly seizures and development delay (MCSZ) [MIM:613402]. It is characterized by microcephaly, infantile-onset seizures, severe intellectual disability and delayed motor milestones with absent speech or only achieving a few words. Most patients also have behavioral problems with hyperactivity. Microcephaly is progressive and without neuronal migration or structural abnormalities, consistent with primary microcephaly.
    • 序列相似性In the N-terminal section; belongs to the DNA 3' phosphatase family.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 2''(3'')-polynucleotidase antibody
      • 2'(3')-polynucleotidase antibody
      • Bifunctional polynucleotide phosphatase/kinase antibody
      • DEM 1 antibody
      • DEM1 antibody
      • DNA 5' kinase/3' phosphatase antibody
      • DNA 5''-kinase/3''-phosphatase antibody
      • EIEE10 antibody
      • Homo sapiens polynucleotide kinase 3' phosphatase (PNKP) antibody
      • MCSZ antibody
      • PNK 1 antibody
      • PNK1 antibody
      • Pnkp antibody
      • PNKP DNA kinase antibody
      • PNKP_HUMAN antibody
      • Polynucleotide 3'-phosphatase antibody
      • Polynucleotide 5' hydroxyl kinase antibody
      • Polynucleotide 5''-hydroxyl-kinase antibody
      • Polynucleotide kinase 3 prime phosphatase antibody
      • Polynucleotide kinase 3' phosphatase antibody
      • Polynucleotide Kinase antibody
      • Polynucleotide kinase-3''-phosphatase antibody
      see all

    Anti-PNK antibody 图像

    • ab84374 at 1/250, staining human PNK in a section of human ovarian carcinoma by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
    • ab84374 at 1/250, staining human PNK in a section of human ovarian carcinoma by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

    Anti-PNK antibody (ab84374)参考文献

    ab84374 has not yet been referenced specifically in any publications.

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