概述

  • 产品名称Anti-PMM2抗体
    参阅全部 PMM2 一抗
  • 描述
    兔多克隆抗体to PMM2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-184 of Human PMM2.

  • 阳性对照
    • HeLa and HepG2 whole cell lysates; 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab96399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 28 kDa.

靶标

  • 功能Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
  • 通路Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
  • 疾病相关Defects in PMM2 are the cause of congenital disorder of glycosylation type 1A (CDG1A) [MIM:212065]; also known as carbohydrate-deficient glycoprotein syndrome type Ia (CDGS1A) or Jaeken syndrome. Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1A is an autosomal recessive disorder characterized by a severe encephalopathy with axial hypotonia, abnormal eye movement, and pronounced psychomotor retardation, as well as peripheral neuropathy, cerebellar hypoplasia, and retinitis pigmentosa. Patients show a peculiar distribution of subcutaneous fat, nipple retraction, and hypogonadism.
  • 序列相似性Belongs to the eukaryotic PMM family.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI585868 antibody
    • BOS_22465 antibody
    • C86848 antibody
    • CDG 1 antibody
    • CDG1 antibody
    • CDG1a antibody
    • CDGS antibody
    • MGC127449 antibody
    • Phosphomannomutase 2 antibody
    • PMM 2 antibody
    • Pmm2 antibody
    • PMM2_HUMAN antibody
    see all

Anti-PMM2 antibody 图像

  • All lanes : Anti-PMM2 antibody (ab96399) at 1/1000 dilution

    Lane 1 : HeLa whole cell lysate
    Lane 2 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 28 kDa

Anti-PMM2 antibody (ab96399)参考文献

ab96399 has not yet been referenced specifically in any publications.

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