概述

  • 产品名称Anti-PLOD3抗体
    参阅全部 PLOD3 一抗
  • 描述
    小鼠多克隆抗体to PLOD3
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human PLOD3 (NP_001075.1)

  • 阳性对照
    • HepG2 cell lysate, PLOD3 transfected 293T cell lysate and HeLa cell

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG

相关产品

应用

Our Abpromise guarantee covers the use of ab89263 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ICC/IF
  • 应用说明ICC/IF: Use at a concentration of 10 µg/ml.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 85 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
    • 疾病相关Defects in PLOD3 are the cause of lysyl hydroxylase 3 deficiency (LH3 deficiency) [MIM:612394]; also known as bone fragility with contractures arterial rupture and deafness. LH3 deficiency is a connective tissue disorder. The syndrome is characterized by congenital malformations severely affecting many tissues and organs and revealing features of several collagen disorders, most of them involving COL2A1 (type II collagen). The findings suggest that the failure of lysyl hydroxylation and hydroxylysyl carbohydrate addition, which affects many collagens, is the molecular basis of this syndrome.
    • 序列相似性Contains 1 Fe2OG dioxygenase domain.
    • 细胞定位Rough endoplasmic reticulum membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 2-oxoglutarate 5-dioxygenase 3 antibody
      • bone protein I antibody
      • BP-I antibody
      • LH3 antibody
      • Lysine hydroxylase 3 antibody
      • Lysyl hydroxylase 3 antibody
      • Plod3 antibody
      • PLOD3_HUMAN antibody
      • Procollagen lysine,2 oxoglutarate 5 dioxygenase 3 precursor antibody
      • Procollagen-lysine antibody
      see all

    Anti-PLOD3 antibody 图像

    • Anti-PLOD3 antibody (ab89263) at 5 µg/ml + HepG2 cel lysate at 50 µg

      Predicted band size : 85 kDa
    • All lanes : Anti-PLOD3 antibody (ab89263) at 5 µg/ml

      Lane 1 : PLOD3 transfected 293T cell lysate
      Lane 2 : Non-transfected lysate

      Lysates/proteins at 50 µg per lane.


      Predicted band size : 85 kDa
    • ab89263 at 10µg/ml staining PLOD3 on HeLa cell by immunofluorescence

    Anti-PLOD3 antibody (ab89263)参考文献

    ab89263 has not yet been referenced specifically in any publications.

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