概述

  • 产品名称
  • 描述
    兔多克隆抗体to PLOD3
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 85-113 of Human PLOD3 (NP_001075.1)

  • 阳性对照
    • MDA-MB435 cell line lysates.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab113038 was purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG

应用

Our Abpromise guarantee covers the use of ab113038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 85 kDa.

靶标

  • 功能
    Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
  • 疾病相关
    Defects in PLOD3 are the cause of lysyl hydroxylase 3 deficiency (LH3 deficiency) [MIM:612394]; also known as bone fragility with contractures arterial rupture and deafness. LH3 deficiency is a connective tissue disorder. The syndrome is characterized by congenital malformations severely affecting many tissues and organs and revealing features of several collagen disorders, most of them involving COL2A1 (type II collagen). The findings suggest that the failure of lysyl hydroxylation and hydroxylysyl carbohydrate addition, which affects many collagens, is the molecular basis of this syndrome.
  • 序列相似性
    Contains 1 Fe2OG dioxygenase domain.
  • 细胞定位
    Rough endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2-oxoglutarate 5-dioxygenase 3 antibody
    • bone protein I antibody
    • BP-I antibody
    • LH3 antibody
    • Lysine hydroxylase 3 antibody
    • Lysyl hydroxylase 3 antibody
    • Plod3 antibody
    • PLOD3_HUMAN antibody
    • Procollagen lysine,2 oxoglutarate 5 dioxygenase 3 precursor antibody
    • Procollagen-lysine antibody
    see all

Anti-PLOD3 antibody 图像

  • Anti-PLOD3 antibody (ab113038) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

    Predicted band size : 85 kDa

实验方案

Anti-PLOD3 antibody (ab113038)参考文献

ab113038 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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