概述

  • 产品名称Anti-PLGF抗体[RM0010-8F09]
    参阅全部 PLGF 一抗
  • 描述
    大鼠单克隆抗体[RM0010-8F09] to PLGF
  • 特异性ab51654 recognizes mouse PLGF.
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Recombinant full length protein (Mouse)

性能

应用

Our Abpromise guarantee covers the use of ab51654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100.
WB 1/400 - 1/1000. Predicted molecular weight: 25 kDa.

靶标

  • 功能Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
  • 组织特异性While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
  • 序列相似性Belongs to the PDGF/VEGF growth factor family.
  • 结构域Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • D12S1900 antibody
    • Pgf antibody
    • PGFL antibody
    • PIGF antibody
    • Placenta growth factor antibody
    • Placental growth factor antibody
    • Placental growth factor, vascular endothelial growth factor related protein antibody
    • PlGF 2 antibody
    • PlGF antibody
    • PLGF_HUMAN antibody
    • PlGF2 antibody
    • SHGC 10760 antibody
    see all

Anti-PLGF antibody [RM0010-8F09] 图像

  • ab51654 at 1/100 dilution, staining PLGF in LPS exposed mouse lung tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-PLGF antibody [RM0010-8F09] (ab51654)参考文献

This product has been referenced in:
  • Li Y  et al. Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice. Nutrients 7:6425-45 (2015). WB ; Mouse . Read more (PubMed: 26247969) »
  • Saad AF  et al. Effects of pravastatin on angiogenic and placental hypoxic imbalance in a mouse model of preeclampsia. Reprod Sci 21:138-45 (2014). Mouse . Read more (PubMed: 23749761) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"