概述

  • 产品名称
  • 描述
    山羊多克隆抗体to PLGF
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Pig
  • 免疫原

    Synthetic peptide:

    NVTMQLLKIRSGDR

    by a Cysteine residue linker, corresponding to internal sequence amino acids 101-114 of Human PLGF (NP_002623.2)

  • 阳性对照
    • Human Placenta lysate

性能

应用

Our Abpromise guarantee covers the use of ab99250 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 25 kDa).

靶标

  • 功能
    Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
  • 组织特异性
    While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
  • 序列相似性
    Belongs to the PDGF/VEGF growth factor family.
  • 结构域
    Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
  • 翻译后修饰
    N-glycosylated.
  • 细胞定位
    Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • D12S1900 antibody
    • Pgf antibody
    • PGFL antibody
    • PIGF antibody
    • Placenta growth factor antibody
    • Placental growth factor antibody
    • Placental growth factor, vascular endothelial growth factor related protein antibody
    • PlGF 2 antibody
    • PlGF antibody
    • PLGF_HUMAN antibody
    • PlGF2 antibody
    • SHGC 10760 antibody
    see all

图片

实验方案

文献

This product has been referenced in:
  • Ott CJ  et al. Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. Proc Natl Acad Sci U S A 106:19934-9 (2009). Read more (PubMed: 19897727) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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