概述

  • 产品名称Anti-PLCZ1抗体
    参阅全部 PLCZ1 一抗
  • 描述
    兔多克隆抗体to PLCZ1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 322-572 of Human PLCZ1 (BC125067).

  • 阳性对照
    • HeLa cell, Human fetal liver and fetal kidney lysates, Human fetal testis tissue

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab124446 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 70 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
  • 组织特异性Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.
  • 序列相似性Contains 1 C2 domain.
    Contains 1 EF-hand domain.
    Contains 1 PI-PLC X-box domain.
    Contains 1 PI-PLC Y-box domain.
  • 结构域The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
    The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.
  • 细胞定位Nucleus. Cytoplasm > perinuclear region. Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase zeta 1 antibody
    • 1-phosphatidylinositol-4 antibody
    • 5-bisphosphate phosphodiesterase zeta-1 antibody
    • MGC149685 antibody
    • NYD SP27 antibody
    • Phosphoinositide phospholipase C zeta 1 antibody
    • Phosphoinositide phospholipase C-zeta-1 antibody
    • Phospholipase C zeta 1 antibody
    • Phospholipase C-zeta-1 antibody
    • PI phospholipase C zeta 1 antibody
    • PLC zeta 1 antibody
    • PLC-zeta-1 antibody
    • PLCZ1 antibody
    • PLCZ1_HUMAN antibody
    • PLCzeta antibody
    • Testis development protein NYD SP27 antibody
    • Testis development related NYD SP27 antibody
    • Testis-development protein NYD-SP27 antibody
    see all

Anti-PLCZ1 antibody 图像

  • ab124446 at 1/100 dilution staining PLCZ1 in Human fetal testis tissue by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-PLCZ1 antibody (ab124446)参考文献

ab124446 has not yet been referenced specifically in any publications.

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