概述

  • 产品名称Anti-PLCD4抗体
    参阅全部 PLCD4 一抗
  • 描述
    兔多克隆抗体to PLCD4
  • 经测试应用适用于: WB, ELISA, ICCmore details
  • 种属反应性
    与反应: Sea Urchin
  • 免疫原

    Synthetic peptides derived from internal parts of Purple Sea Urchin PLCD4.

性能

应用

Our Abpromise guarantee covers the use of ab101148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 86 kDa.
ELISA Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.

靶标

  • 功能Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
  • 组织特异性Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.
  • 序列相似性Contains 1 C2 domain.
    Contains 3 EF-hand domains.
    Contains 1 PH domain.
    Contains 1 PI-PLC X-box domain.
    Contains 1 PI-PLC Y-box domain.
  • 结构域The PDZ-binding motif mediates the interaction with GRIP1.
    The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
    The PH domain is not a critical determinant of the membrane localization.
  • 细胞定位Membrane. Nucleus. Cytoplasm. Endoplasmic reticulum. Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
  • Information by UniProt
  • 别名
    • 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase delta 4 antibody
    • 1-phosphatidylinositol 4 antibody
    • 5-bisphosphate phosphodiesterase delta-4 antibody
    • hPLCD4 antibody
    • MGC12837 antibody
    • Phosphoinositide phospholipase C delta 4 antibody
    • Phosphoinositide phospholipase C-delta-4 antibody
    • Phospholipase C delta 4 antibody
    • Phospholipase C-delta-4 antibody
    • PLC delta 4 antibody
    • PLC delta4 antibody
    • PLC-delta-4 antibody
    • PLCD4 antibody
    • PLCD4_HUMAN antibody
    see all

Anti-PLCD4 antibody (ab101148)参考文献

ab101148 has not yet been referenced specifically in any publications.

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