Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 59-89 of Human PLC-delta-3 (NP_588614.1).
Mouse liver tissue lysates.
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Preservative: 0.09% Sodium azide
Constituent: 99% PBS
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Immunogen affinity purified
ab123668 is purified through a protein A column, followed by peptide affinity purification.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 89 kDa.
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
Present in corneal epithelial cells (at protein level).
Contains 1 C2 domain.
Contains 3 EF-hand domains. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.
The C2 domain is a Ca(2+)-dependent membrane-targeting module.
The PH domain mediates interaction with the surface membrane by binding to PIP2.
Membrane. Cytoplasm. Cleavage furrow. Localizes at the cleavage furrow during cytokinesis.
Information by UniProt
5-bisphosphate phosphodiesterase delta-3 antibody
Phosphoinositide phospholipase C-delta-3 antibody
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"