概述

  • 产品名称Anti-Platelet抗体[AIP21]
  • 描述
    大鼠单克隆抗体[AIP21] to Platelet
  • 特异性ab112238 detects an unidentified antigen on mouse platelets that is not identical to CD9, GPIV or integrins. This antigen is also present on B16F10 and KN-3 cells, but not thymocytes or splenocytes.
  • 经测试应用适用于: Functional Studies, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse Platelets

  • 常规说明


    ab112238 induces mouse platelet aggregation in the absence of plasma components via an FcR-independent mechanism. A dramatic increase in tyrosine phosphorylation of the 52 kDa Shc protein was observed during AIP21-mediated platelet aggregation.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • Primary antibody说明ab112238 induces mouse platelet aggregation in the absence of plasma components via an FcR-independent mechanism. A dramatic increase in tyrosine phosphorylation of the 52 kDa Shc protein was observed during AIP21-mediated platelet aggregation.
  • 克隆单克隆
  • 克隆编号AIP21
  • 同种型IgM
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab112238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use 1µg for 106 cells. ab35768-Rat monoclonal IgM, is suitable for use as an isotype control with this antibody.

靶标

  • 相关性Platelets or thrombocytes are the blood cell fragments that are involved in the cellular mechanisms that lead to the formation of blood clots. Low levels or dysfunction predisposes for bleeding, while high levels, although usually asymptomatic, may increase the risk of thrombosis. Like red blood cells, platelets are anuclear (no cell nucleus) and discoid (disc shaped); they measure 1.5 to 3.0 µm in diameter. The body has a very limited reserve of platelets, so they can be rapidly depleted. They contain RNA, a canalicular system, and several different types of granules; lysosomes (containing acid hydrolases), dense bodies (containing ADP, ATP serotonin and calcium) and alpha granules (containing fibrinogen, factor V, vitronectin, thrombospondin and von Willebrand factor), the contents of which are released upon activation of the platelet. These granule contents play an important role in both hemostasis and in the inflammatory response.

Anti-Platelet antibody [AIP21] (ab112238)参考文献

This product has been referenced in:
  • Kato Y  et al. A novel anti-platelet monoclonal antibody induces mouse platelet aggregation through an Fc receptor-independent mechanism. Biochem Biophys Res Commun 242:250-5 (1998). Read more (PubMed: 9446779) »

See 1 Publication for this product

Product Wall

For ab112238: DISCOUNT CODE: ***
For ab115679: DISCOUNT CODE: ***
Expiration date: November 19, 2012

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"