Anti-Plasma Kallikrein 1B抗体(ab116517)

概述

  • 产品名称Anti-Plasma Kallikrein 1B抗体
    参阅全部 Plasma Kallikrein 1B 一抗
  • 描述
    兔多克隆抗体to Plasma Kallikrein 1B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 507-537 of Human Plasma Kallikrein 1B (NP_000883.2).

  • 阳性对照
    • K562 cell line lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab116517 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab116517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 71 kDa.

靶标

  • 功能The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
  • 疾病相关Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
  • 序列相似性Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Fletcher factor antibody
    • kallikrein B plasma antibody
    • Kallikrein B plasma (Fletcher factor) 1 antibody
    • Kallikrein B, plasma 1 antibody
    • Kininogenin antibody
    • KLK3 antibody
    • KLKB1 antibody
    • KLKB1_HUMAN antibody
    • Plasma kallikrein antibody
    • Plasma kallikrein B1 antibody
    • Plasma kallikrein light chain antibody
    • Plasma prekallikrein antibody
    • PPK antibody
    • Prekallikrein antibody
    see all

Anti-Plasma Kallikrein 1B antibody 图像

  • Anti-Plasma Kallikrein 1B antibody (ab116517) at 1/100 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 71 kDa

Anti-Plasma Kallikrein 1B antibody (ab116517)参考文献

ab116517 has not yet been referenced specifically in any publications.

Product Wall

Following up my previous message, the immunogen for ab116517 is in fact contained within the light chain sequence. (I asked for the homology to be checked using the sequence below, UniProt P14272 aa 391-638).

IVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGS...

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The alignment of the immunogen for ab116517, Anti-Plasma Kallikrein 1B antibody, with the rat protein gives the following:

Identities = 11/15 (73%), Positives = 12/15 (80%), Gaps = 0/15 (0%)

The lab neglected to tell me whether th...

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I will send the alignment results for ab116517, hopefully later today.

I am glad ab1006 is working, at least with human samples. If you have time, we encourage our customers to send us reviews of their results, positive or negative, via our ...

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This is frustrating for us too, finding incorrect information on our datasheets. We try to minimize it but there is clearly work to be done.

I did not realize you had already purchased the antibody. If you would still like to try it with rat...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"