Anti-PLA2R抗体(ab80054)
Key features and details
- Rabbit polyclonal to PLA2R
- Suitable for: IHC-Fr, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PLA2R抗体
参阅全部 PLA2R 一抗 -
描述
兔多克隆抗体to PLA2R -
宿主
Rabbit -
经测试应用
适用于: IHC-Fr, WBmore details -
种属反应性
与反应: Human
预测可用于: Rabbit, Cow -
免疫原
Synthetic peptide derived from the C terminal domain of human PLA2R
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常规说明
We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 23rd June 2017. The following lots are still unpurified and still in stock as of 23rd June 2017 - GR3173938-1, GR3173938-3, GR3173938-4, GR3173938-5, GR306201-4, GR306201-5, GR3173938-2, GR306201-3, GR306201-2, GR281777-4. Lot numbers other than GR3173938-1, GR3173938-3, GR3173938-4, GR3173938-5, GR306201-4, GR306201-5, GR3173938-2, GR306201-3, GR306201-2, GR281777-4 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab80054于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-Fr | (1) |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
|
说明 |
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IHC-Fr
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
靶标
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功能
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. -
组织特异性
Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. -
序列相似性
Contains 8 C-type lectin domains.
Contains 1 fibronectin type-II domain.
Contains 1 ricin B-type lectin domain. -
结构域
C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
The endocytosis signal probably mediates endocytosis via clathrin-coated pits. -
翻译后修饰
The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 317777 Cow
- Entrez Gene: 22925 Human
- Entrez Gene: 100009180 Rabbit
- Omim: 604939 Human
- SwissProt: P49259 Cow
- SwissProt: Q13018 Human
- SwissProt: P49260 Rabbit
- Unigene: 410477 Human
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别名
- 180 kDa secretory phospholipase A2 receptor antibody
- C-type lectin domain family 13 member C antibody
- CLEC13C antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab80054 被引用在 4 文献中.
- Ramachandran R et al. Membranous Nephropathy With Light Chain Restricted Deposits. Nephrology (Carlton) N/A:N/A (2018). PubMed: 29633425
- Kumar V et al. Primary membranous nephropathy in adolescence: A prospective study. Nephrology (Carlton) 22:678-683 (2017). PubMed: 27334445
- Ramachandran R et al. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians. Nephrol Dial Transplant 31:1486-93 (2016). PubMed: 26673907
- Kumar V et al. Antibodies to m-type phospholipase A2 receptor in children with idiopathic membranous nephropathy. Nephrology (Carlton) 20:572-5 (2015). PubMed: 26194981