概述

  • 产品名称Anti-PLA2G4D抗体
    参阅全部 PLA2G4D 一抗
  • 描述
    兔多克隆抗体to PLA2G4D
  • 特异性Detects endogenous levels of total PLA2G4D protein.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from an internal sequence of Human PLA2G4D.

  • 阳性对照
    • Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab111126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.
  • 组织特异性Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin.
  • 序列相似性Contains 1 C2 domain.
    Contains 1 PLA2c domain.
  • 结构域The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • 细胞定位Cytoplasm > cytosol. Cytoplasmic vesicle membrane. Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cPLA2 delta antibody
    • cPLA2-delta antibody
    • cPLA2delta antibody
    • Cytosolic phospholipase A2 delta antibody
    • PA24D_HUMAN antibody
    • Phospholipase A2 group IVD antibody
    • phospholipase A2, group IVD (cytosolic) antibody
    • Pla2g4d antibody
    see all

Anti-PLA2G4D antibody 图像

  • ab111126, at a 1/50 dilution, staining PLA2G4D in paraffin embedded Human brain tissue by Immunohistochemistry. The image on the right is from cells treated with the synthesized peptide.

Anti-PLA2G4D antibody (ab111126)参考文献

ab111126 has not yet been referenced specifically in any publications.

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