• 产品名称Anti-PKM2抗体
    参阅全部 PKM2 一抗
  • 描述
    山羊多克隆抗体to PKM2
  • 特异性The antibody is raised against pyruvate kinase isolated from rabbit muscle. Reactivity with specific PK (PKM1, PKLR) has not been assessed.
  • 经测试应用适用于: ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Rabbit, Human
    预测可用于: all Mammals
  • 免疫原

    Purified pyruvate kinase from Rabbit muscle.

  • 阳性对照
    • Uterus tissue.




Our Abpromise guarantee covers the use of ab79070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.


  • 功能Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
  • 组织特异性Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.
  • 通路Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
  • 序列相似性Belongs to the pyruvate kinase family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Nucleus. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CTHBP antibody
    • Cytosolic thyroid hormone binding protein antibody
    • Cytosolic thyroid hormone-binding protein antibody
    • KPYM_HUMAN antibody
    • MGC3932 antibody
    • OIP 3 antibody
    • OIP-3 antibody
    • OIP3 antibody
    • OPA interacting protein 3 antibody
    • Opa-interacting protein 3 antibody
    • p58 antibody
    • PK muscle type antibody
    • PK, muscle type antibody
    • PK2 antibody
    • PK3 antibody
    • PKM antibody
    • PKM2 antibody
    • pykm antibody
    • Pyruvate kinase 2/3 antibody
    • Pyruvate kinase 3 antibody
    • Pyruvate kinase isozymes M1/M2 antibody
    • Pyruvate kinase muscle antibody
    • Pyruvate kinase muscle isozyme antibody
    • pyruvate kinase PKM antibody
    • Pyruvate kinase, muscle 2 antibody
    • TCB antibody
    • THBP1 antibody
    • Thyroid hormone binding protein 1 antibody
    • Thyroid hormone binding protein cytosolic antibody
    • Thyroid hormone-binding protein 1 antibody
    • Tumor M2 PK antibody
    • Tumor M2-PK antibody
    see all

Anti-PKM2 antibody 图像

  • ab79070, at 5µg/ml, staining PKM2 in uterus tissue by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-PKM2 antibody (ab79070)参考文献

ab79070 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10000µg/mL · Temperature: 25°C
Sample Human Cell (Cholangiocarcinoma cell)
Specification Cholangiocarcinoma cell
Permeabilization Yes - 0.25% TritonX-100
Fixative Formaldehyde

Abcam user community

Verified customer

提交于 May 26 2014

J’ai contacté le laboratoire est malheureusement l’épitope d’ab79070 n’a pas été déterminé.

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (ECR 293 cell line)
Specification ECR 293 cell line
Fixative Formaldehyde
Permeabilization Yes - 0.1% Triton X-100
Blocking step BSA as blocking agent for 15 minute(s) · Concentration: 3% · Temperature: 25°C

Dr. Ismail Hendaoui

Verified customer

提交于 Feb 04 2013

Merci pour votre appel de hier.

La laboratoire à pu me confirmer, que pour l'IP1 x 107 cellules ont été lysées et resuspendues en 0.2ml. Ensuite, ils ont ajouté de 0.5à 5 ul de cet anticorps et incub&...

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