Anti-PKLR抗体[AT1E3] (ab119500)

概述

  • 产品名称Anti-PKLR抗体[AT1E3]
    参阅全部 PKLR 一抗
  • 描述
    小鼠单克隆抗体[AT1E3] to PKLR
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 47-574 of Human PKLR, purified from E. coli (NP_000289)

  • 阳性对照
    • 293T cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab119500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 62 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Plays a key role in glycolysis.
  • 通路Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
  • 疾病相关Defects in PKLR are the cause of pyruvate kinase hyperactivity (PKHYP) [MIM:102900]; also known as high red cell ATP syndrome. This autosomal dominant phenotype is characterized by increase of red blood cell ATP.
    Defects in PKLR are the cause of pyruvate kinase deficiency of red cells (PKRD) [MIM:266200]. A frequent cause of hereditary non-spherocytic hemolytic anemia. Clinically, pyruvate kinase-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at birth, severe transfusion-dependent chronic hemolysis, moderate hemolysis with exacerbation during infection, to a fully compensated hemolysis without apparent anemia.
  • 序列相似性Belongs to the pyruvate kinase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EC 2.7.1.40 antibody
    • KPYR_HUMAN antibody
    • L-PK antibody
    • Pk-1 antibody
    • PK1 antibody
    • PKL antibody
    • Pklg antibody
    • Pklr antibody
    • PKR antibody
    • PKRL antibody
    • Pyruvate kinase 1 antibody
    • Pyruvate kinase isozymes R/L antibody
    • Pyruvate kinase liver and blood cell antibody
    • Pyruvate kinase liver and RBC antibody
    • Pyruvate kinase liver and red blood cell antibody
    • Pyruvate kinase liver type antibody
    • Pyruvate kinase type L antibody
    • Pyruvate kinase, red cell type antibody
    • R type/L type pyruvate kinase antibody
    • R-PK antibody
    • R-type/L-type pyruvate kinase antibody
    • Red cell/liver pyruvate kinase antibody
    • RPK antibody
    see all

Anti-PKLR antibody [AT1E3] 图像

  • Anti-PKLR antibody [AT1E3] (ab119500) at 1/500 dilution + 293T cell lysate at 40 µg

    Secondary
    goat anti-mouse HRP
    Developed using the ECL technique

    Predicted band size : 62 kDa
    Observed band size : 62 kDa

Anti-PKLR antibody [AT1E3] (ab119500)参考文献

ab119500 has not yet been referenced specifically in any publications.

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