Anti-PKLR抗体(ab96604)

概述

• 产品名称Anti-PKLR抗体
  参阅全部 PKLR 一抗
• 描述
  兔多克隆抗体to PKLR
• 经测试应用适用于: WB, ICC/IFmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Cow
• 免疫原

  Recombinant fragment, corresponding to a region within the N terminal amino acids 1-230 of Human PKLR.

• 阳性对照
  • 293T, A431, H1299, HeLa, HepG2, Raji cell lysates

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• Concentration information loading...
• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of carbohydrates

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Carbohydrate metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa whole cell lysate (ab29545)
  • Raji whole cell lysate (ab30124)
  • HepG2 whole cell lysate (ab7900)
  • HEK293 whole cell lysate (ab7902)
  • A431 whole cell lysate (ab7909)

应用

靶标

• 功能Plays a key role in glycolysis.
• 通路Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
• 疾病相关Defects in PKLR are the cause of pyruvate kinase hyperactivity (PKHYP) [MIM:102900]; also known as high red cell ATP syndrome. This autosomal dominant phenotype is characterized by increase of red blood cell ATP.
  Defects in PKLR are the cause of pyruvate kinase deficiency of red cells (PKRD) [MIM:266200]. A frequent cause of hereditary non-spherocytic hemolytic anemia. Clinically, pyruvate kinase-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at birth, severe transfusion-dependent chronic hemolysis, moderate hemolysis with exacerbation during infection, to a fully compensated hemolysis without apparent anemia.
• 序列相似性Belongs to the pyruvate kinase family.

• Target information above from: UniProt accession P30613 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 539579 Cow
  • Entrez Gene: 5313 Human
  • Entrez Gene: 18770 Mouse
  • Entrez Gene: 24651 Rat
  • Omim: 609712 Human
  • SwissProt: P30613 Human
  • SwissProt: P53657 Mouse
  • SwissProt: P12928 Rat

  • Unigene: 95990 Human
  • Unigene: 383180 Mouse
  • Unigene: 48821 Rat

  see all
• 别名
  • EC 2.7.1.40 antibody
  • KPYR_HUMAN antibody
  • L-PK antibody

  • Pk-1 antibody
  • PK1 antibody
  • PKL antibody
  • Pklg antibody
  • Pklr antibody
  • PKR antibody
  • PKRL antibody
  • Pyruvate kinase 1 antibody
  • Pyruvate kinase isozymes R/L antibody
  • Pyruvate kinase liver and blood cell antibody
  • Pyruvate kinase liver and RBC antibody
  • Pyruvate kinase liver and red blood cell antibody
  • Pyruvate kinase liver type antibody
  • Pyruvate kinase type L antibody
  • Pyruvate kinase, red cell type antibody
  • R type/L type pyruvate kinase antibody
  • R-PK antibody
  • R-type/L-type pyruvate kinase antibody
  • Red cell/liver pyruvate kinase antibody
  • RPK antibody

  see all