Anti-PKHD1抗体(ab122160)
Key features and details
- Rabbit polyclonal to PKHD1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PKHD1抗体
参阅全部 PKHD1 一抗 -
描述
兔多克隆抗体to PKHD1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
antigen sequence: KTTTVNYVRD TLSNPRGWMA LLLDQETYSL QSENLWINRS LQYSATFDNF APGNYLLLVH TDLPPYPDIL LRCGSRVGLS FPFLPSPGQN Q, corresponding to amino acids 2596-2686 of Human PKHD1.
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阳性对照
- Human liver tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab122160于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
May be a receptor protein that acts in collecting-duct and biliary differentiation. -
组织特异性
Predominantly expressed in fetal and adult kidney. Also present in the adult pancreas, but at much lower levels. Detectable in fetal and adult liver. Rather indistinct signal in fetal brain. -
疾病相关
Defects in PKHD1 are the cause of polycystic kidney disease autosomal recessive (ARPKD) [MIM:263200]. ARPKD is a severe form of polycystic kidney disease affecting the kidneys and the hepatic biliary tract. The clinical spectrum is widely variable, with most cases presenting during infancy. The fetal phenotypic features classically include enlarged and echogenic kidneys, as well as oligohydramnios secondary to a poor urine output. Up to 50% of the affected neonates die shortly after birth, as a result of severe pulmonary hypoplasia and secondary respiratory insufficiency. In the subset that survives the perinatal period, morbidity and mortality are mainly related to severe systemic hypertension, renal insufficiency, and portal hypertension due to portal-tract fibrosis. -
序列相似性
Contains 2 G8 domains.
Contains 12 IPT/TIG domains.
Contains 9 PbH1 repeats. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 5314 Human
- Omim: 606702 Human
- SwissProt: P08F94 Human
- Unigene: 662050 Human
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别名
- ARPKD antibody
- FCYT antibody
- Fibrocystin antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab122160 尚未被引用在任何文献中。