Anti-PKC delta (phospho S664)抗体(ab78199)

概述

  • 产品名称Anti-PKC delta (phospho S664)抗体
    参阅全部 PKC delta 一抗
  • 描述
    兔多克隆抗体to PKC delta (phospho S664)
  • 特异性Recognizes phospho-PKC delta (Ser664). Weaker interaction with mouse and rat PKCd (Ser662) and PKCa (Ser657) and PKCßII (Ser662).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to amino acid region encompassing the human phospho-PKC delta (Ser664).

  • 阳性对照
    • RIPA lysate of PMA-treated K562 cells.

性能

应用

Our Abpromise guarantee covers the use of ab78199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 78 kDa (predicted molecular weight: 78 kDa).

靶标

  • 功能This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 C2 domain.
    Contains 2 phorbol-ester/DAG-type zinc fingers.
    Contains 1 protein kinase domain.
  • 结构域The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor.
    The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.
  • 翻译后修饰Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity.
  • 细胞定位Cytoplasm. Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CVID9 antibody
    • D14Ertd420e antibody
    • Kinase PKC delta antibody
    • KPCD antibody
    • KPCD_HUMAN antibody
    • MAY 1 antibody
    • MAY1 antibody
    • MGC49908 antibody
    • nPKC delta antibody
    • nPKC-delta antibody
    • PCKd antibody
    • PKC d antibody
    • PKC delta antibody
    • PKCD antibody
    • PKCdelta antibody
    • PRKC D antibody
    • PRKC delta antibody
    • Prkcd antibody
    • Protein Kinase C delta antibody
    • Protein kinase C delta type antibody
    • Protein kinase C delta VIII antibody
    • Protein Kinase Cdelta antibody
    • Tyrosine protein kinase PRKCD antibody
    see all

Anti-PKC delta (phospho S664) antibody 图像

  • All lanes : Anti-PKC delta (phospho S664) antibody (ab78199) at 1/1000 dilution

    Lane 1 : PMA treated K562 cell lysate
    Lane 2 : PMA treated K562 cell lysate with peptide immunogen, phospho-Ser664
    Lane 3 : PMA treated K562 cell lysate with lambda phosphatase


    Predicted band size : 78 kDa
    Observed band size : 78 kDa

Anti-PKC delta (phospho S664) antibody (ab78199)参考文献

ab78199 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab78199.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"