Anti-PKA regulatory subunit I beta抗体(ab38225)

概述

  • 产品名称Anti-PKA regulatory subunit I beta抗体
    参阅全部 PKA regulatory subunit I beta 一抗
  • 描述
    兔多克隆抗体to PKA regulatory subunit I beta
  • 特异性This antibody is specific for PKA regulatory subunit I beta.
  • 经测试应用适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the sequence of human PKA regulatory subunit I beta within aa 1-100.

  • 阳性对照
    • Human breast carcinoma tissue and mouse liver tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab38225 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Detects a band of approximately 43 kDa (predicted molecular weight: 43 kDa).

靶标

  • 组织特异性Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 序列相似性Belongs to the cAMP-dependent kinase regulatory chain family.
    Contains 2 cyclic nucleotide-binding domains.
  • 翻译后修饰The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cAMP dependent protein kinase type I beta regulatory subunit antibody
    • cAMP-dependent protein kinase type I-beta regulatory subunit antibody
    • KAP1_HUMAN antibody
    • PKARI beta antibody
    • PRKAR 1 antibody
    • PRKAR 1B antibody
    • PRKAR1 antibody
    • Prkar1b antibody
    • PRKAR1B protein antibody
    • Protein kinase cAMP dependent regulatory type I beta antibody
    • RIbeta antibody
    see all

Anti-PKA regulatory subunit I beta antibody 图像

  • Anti-PKA regulatory subunit I beta antibody (ab38225) at 1/100 dilution + mouse liver tissue lysate

    Secondary
    HRP-anti-rabbit
    Developed using the ECL technique

    Predicted band size : 43 kDa
    Observed band size : 43 kDa
  • Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with ab38225 at a 1/50 dilution, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

    This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PKA regulatory subunit I beta antibody (ab38225)参考文献

This product has been referenced in:
  • Wong TH  et al. PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain 137:1361-73 (2014). Read more (PubMed: 24722252) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"