1/100. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
功能Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
组织特异性Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
序列相似性Belongs to the cAMP-dependent kinase regulatory chain family. Contains 2 cyclic nucleotide-binding domains.
翻译后修饰Phosphorylated by the activated catalytic chain.
细胞定位Cytoplasm. Cell membrane. Colocalizes with PJA2 in the cytoplasm and the cell membrane.
HEK293T cells transfected with either a PKA R2 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained using ab124400 at 1/100 dilution, and then analyzed by flow cytometry.
Anti-PKA R2 antibody [5F1] (ab124400)参考文献
This product has been referenced in:
Hedrick ED et al. Differential PKA activation and AKAP association determines cell fate in cancer cells. J Mol Signal8:10 (2013).
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