Anti-PKA beta (catalytic subunit) (phospho T198)抗体(ab118531)

概述

  • 产品名称Anti-PKA beta (catalytic subunit) (phospho T198)抗体
    参阅全部 PKA beta (catalytic subunit) 一抗
  • 描述
    兔多克隆抗体to PKA beta (catalytic subunit) (phospho T198)
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Cow, Pig, Caenorhabditis elegans, Drosophila melanogaster
  • 免疫原

    Synthetic phosphopeptide, conjugated to KLH, corresponding to amino acids 193-202 of Human PKA beta (catalytic subunit) with phosphoThr at position 198 (NP_002722.1).

  • 阳性对照
    • Human Kidney tissue.

相关产品

应用

Our Abpromise guarantee covers the use of ab118531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.
  • 组织特异性Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
  • 细胞定位Cytoplasm. Nucleus. Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody
    • cAMP-dependent protein kinase catalytic subunit beta antibody
    • KAPCB_HUMAN antibody
    • PKA C beta antibody
    • PKA C-beta antibody
    • PKACB antibody
    • Prkacb antibody
    • protein kinase A catalytic subunit beta antibody
    • Protein kinase cAMP dependent catalytic beta antibody
    see all

Anti-PKA beta (catalytic subunit) (phospho T198) antibody 图像

  • Human Kidney tissue (formalin-fixed, paraffin-embedded) stained with ab118531 at 5 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-PKA beta (catalytic subunit) (phospho T198) antibody (ab118531)参考文献

ab118531 has not yet been referenced specifically in any publications.

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