Anti-PIST抗体- C-terminal (ab71191)

概述

  • 产品名称Anti-PIST抗体- C-terminal
    参阅全部 PIST 一抗
  • 描述
    兔多克隆抗体to PIST - C-terminal
  • 经测试应用适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 阳性对照
    • Ramos cell line lysates and human colon carcinoma tisue.

性能

应用

Our Abpromise guarantee covers the use of ab71191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/10 - 1/50.
WB 1/50 - 1/100. Detects a band of approximately 60 kDa (predicted molecular weight: 51 kDa).

靶标

  • 功能Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
  • 组织特异性Ubiquitously expressed.
  • 疾病相关Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
  • 序列相似性Contains 1 PDZ (DHR) domain.
  • 结构域The PDZ domain mediates interactions with FZD5, FZD8, ACCN3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.
    The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ.
  • 细胞定位Cytoplasm. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAL antibody
    • CFTR associated ligand antibody
    • CFTR-associated ligand antibody
    • dJ94G16.2 antibody
    • dJ94G16.2 PIST antibody
    • FIG antibody
    • Fused in glioblastoma antibody
    • Golgi associated PDZ and coiled coil motif containing antibody
    • Golgi associated PDZ and coiled coil motif containing protein antibody
    • Golgi-associated PDZ and coiled-coil motif-containing protein antibody
    • GOPC 1 antibody
    • GOPC antibody
    • GOPC_HUMAN antibody
    • GOPC1 antibody
    • OTTHUMP00000040403 antibody
    • PDZ protein interacting specifically with TC 10 antibody
    • PDZ protein interacting specifically with TC10 antibody
    • PDZ/coiled coil domain binding partner for the rho family GTPase TC 10 antibody
    • PDZ/coiled coil domain binding partner for the rho family GTPase TC10 antibody
    • PIST antibody
    • Protein interacting specifically with Tc 10 antibody
    • Protein interacting specifically with Tc10 antibody
    see all

Anti-PIST antibody - C-terminal 图像

  • Anti-PIST antibody - C-terminal (ab71191) at 1/60 dilution + Ramos cell line lysates at 35 µg

    Predicted band size : 51 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 26 kDa,45 kDa,72 kDa. We are unsure as to the identity of these extra bands.
  • ab71191 at 1/10 dilution, staining PIST in human colon carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PIST antibody - C-terminal (ab71191)参考文献

ab71191 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab71191.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"