概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 序列
      GSSKKVTLSVLSRE-C
    • 氨基酸
      2 to 15

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Pirin antibody (ab21202)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

常规信息

  • 别名
    • 3-dioxygenase PIR
    • Iron binding nuclear protein
    • Pir
    • PIR_HUMAN
    • Pirin
    • Probable quercetin 2
    • probable quercetin 2,3-dioxygenase PIR
    • Probable quercetinase
    see all
  • 功能
    Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).
  • 组织特异性
    Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
  • 通路
    Flavonoid metabolism; quercetin degradation.
  • 序列相似性
    Belongs to the pirin family.
  • 细胞定位
    Nucleus. Cytoplasm. Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
  • Information by UniProt

文献

ab45602 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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