Anti-PIP5KI gamma抗体- N-terminal (ab71820)

概述

  • 产品名称Anti-PIP5KI gamma抗体- N-terminal
    参阅全部 PIP5KI gamma 一抗
  • 描述
    兔多克隆抗体to PIP5KI gamma - N-terminal
  • 经测试应用适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 阳性对照
    • 293 cell lysate and human hepatocarcinoma tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab71820 is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab71820 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Detects a band of approximately 70 kDa (predicted molecular weight: 74 kDa).

靶标

  • 功能Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
  • 疾病相关Defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.
  • 序列相似性Contains 1 PIPK domain.
  • 细胞定位Cell membrane. Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Diphosphoinositide kinase antibody
    • LCCS3 antibody
    • Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody
    • Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody
    • PI51C antibody
    • PI51C_HUMAN antibody
    • PIP5K GAMMA antibody
    • PIP5K1-gamma antibody
    • Pip5k1c antibody
    • PIP5KIgamma antibody
    • PtdIns(4)P 5 kinase gamma antibody
    • PtdIns(4)P-5-kinase 1 gamma antibody
    • Type I PIP kinase antibody
    see all

Anti-PIP5KI gamma antibody - N-terminal 图像

  • Anti-PIP5KI gamma antibody - N-terminal (ab71820) at 1/100 dilution + 293 cell lysate at 12.5 µg

    Predicted band size : 74 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.
  • ab71820 at 1/50 dilution, staining PIP5KI gamma in human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and AEC staining.

Anti-PIP5KI gamma antibody - N-terminal (ab71820)参考文献

ab71820 has not yet been referenced specifically in any publications.

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