RabMAb

Anti-PIP5KI gamma抗体[MAO-R1] (ab109192)

概述

  • 产品名称Anti-PIP5KI gamma抗体[MAO-R1]
    参阅全部 PIP5KI gamma 一抗
  • 描述
    兔单克隆抗体[MAO-R1] to PIP5KI gamma
  • 经测试应用适用于: WB, IPmore details
    不适用于: Flow Cyt,ICC or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant full length Mouse PIP5KI gamma.

  • 阳性对照
    • K562, Human fetal kidney, C6, Neuro-2a, and 293T cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab109192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 80-90 kDa (predicted molecular weight: 73 kDa).
IP 1/10 - 1/100.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IHC-P.
  • 靶标

    • 功能Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
    • 疾病相关Defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.
    • 序列相似性Contains 1 PIPK domain.
    • 细胞定位Cell membrane. Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Diphosphoinositide kinase antibody
      • LCCS3 antibody
      • Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody
      • Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody
      • PI51C antibody
      • PI51C_HUMAN antibody
      • PIP5K GAMMA antibody
      • PIP5K1-gamma antibody
      • Pip5k1c antibody
      • PIP5KIgamma antibody
      • PtdIns(4)P 5 kinase gamma antibody
      • PtdIns(4)P-5-kinase 1 gamma antibody
      • Type I PIP kinase antibody
      see all

    Anti-PIP5KI gamma antibody [MAO-R1] 图像

    • All lanes : Anti-PIP5KI gamma antibody [MAO-R1] (ab109192) at 1/1000 dilution

      Lane 1 : K562 cell lysate
      Lane 2 : Human fetal kidney cell lysate
      Lane 3 : C6 cell lysate
      Lane 4 : Neuro-2a cell lysate
      Lane 5 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 73 kDa

    Anti-PIP5KI gamma antibody [MAO-R1] (ab109192)参考文献

    This product has been referenced in:
    • Tojima T  et al. Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis. J Neurosci 34:7165-78 (2014). Read more (PubMed: 24849351) »

    See 1 Publication for this product

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