Anti-PIP5KI gamma抗体(ab57071)

概述

  • 产品名称Anti-PIP5KI gamma抗体
    参阅全部 PIP5KI gamma 一抗
  • 描述
    小鼠单克隆抗体to PIP5KI gamma
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 561-668 of Human PIP5KI gamma

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2b
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57071 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
    • 疾病相关Defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.
    • 序列相似性Contains 1 PIPK domain.
    • 细胞定位Cell membrane. Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Diphosphoinositide kinase antibody
      • LCCS3 antibody
      • Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody
      • Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody
      • PI51C antibody
      • PI51C_HUMAN antibody
      • PIP5K GAMMA antibody
      • PIP5K1-gamma antibody
      • Pip5k1c antibody
      • PIP5KIgamma antibody
      • PtdIns(4)P 5 kinase gamma antibody
      • PtdIns(4)P-5-kinase 1 gamma antibody
      • Type I PIP kinase antibody
      see all

    Anti-PIP5KI gamma antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57071 PIP5KI gamma antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-PIP5KI gamma antibody (ab57071)参考文献

    ab57071 has not yet been referenced specifically in any publications.

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