概述

  • 产品名称
  • 描述
    兔多克隆抗体to PION
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 536-565 of Human PION (NP_059135.2).

  • 阳性对照
    • NCI-H292 cell lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG

应用

Our Abpromise guarantee covers the use of ab113024 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 98 kDa.

靶标

  • 功能
    Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
  • 组织特异性
    Widely expressed.
  • 序列相似性
    Belongs to the GSAP family.
  • 翻译后修饰
    The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form.
  • 细胞定位
    Golgi apparatus > trans-Golgi network.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A530088I07Rik antibody
    • DKFZp667B242 antibody
    • Gamma-secretase-activating protein 16 kDa C-terminal form antibody
    • GSAP antibody
    • GSAP-16K antibody
    • GSAP_HUMAN antibody
    • MGC126548 antibody
    • Pigeon homolog (Drosophila) antibody
    • Pion antibody
    • Protein pigeon homolog antibody
    • tcag7.1314 antibody
    see all

Anti-PION antibody 图像

  • Anti-PION antibody (ab113024) at 1/100 dilution + NCI-H292 cell lysate at 35 µg

    Predicted band size : 98 kDa

实验方案

Anti-PION antibody (ab113024)参考文献

ab113024 has not yet been referenced specifically in any publications.

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