Anti-Pinin抗体(ab70605)

概述

• 产品名称
  Anti-Pinin抗体
  参阅全部 Pinin 一抗
• 描述
  兔多克隆抗体to Pinin
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Cow, Dog
• 免疫原

  Synthetic peptide conjugated to KLH derived from within residues 400 - 500 of Human Pinin.

  参阅Abcam的专有抗源政策

  (Peptide available as ab89383.)

• 阳性对照
  • This antibody gave a positive signal in Human Lung and Placenta tissue lysates.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HLH / Leucine Zipper
  • HLH

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • RNA Processing
  • Splicing

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Tumor Suppressors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • Other

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
• 组织特异性
  Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
• 序列相似性
  Belongs to the pinin family.
• 翻译后修饰
  Phosphorylated upon DNA damage, probably by ATM or ATR.
• 细胞定位
  Nucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.

• Target information above from: UniProt accession Q9H307 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 403907 Dog
  • Entrez Gene: 5411 Human
  • Entrez Gene: 18949 Mouse
  • Omim: 603154 Human
  • SwissProt: P79149 Dog
  • SwissProt: Q9H307 Human
  • SwissProt: O35691 Mouse
  • Unigene: 409965 Human

  • Unigene: 22347 Mouse

  see all
• 别名
  • 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
  • Desmosome-associated protein antibody
  • Domain-rich serine protein antibody

  • DRS antibody
  • DRS protein antibody
  • DRSP antibody
  • Melanoma metastasis clone A protein antibody
  • MEMA antibody
  • Nuclear protein SDK3 antibody
  • Pinin antibody
  • PININ_HUMAN antibody
  • PNN antibody
  • SR like protein antibody
  • SR-like protein antibody

  see all

实验方案

• Western blot protocols