概述

  • 产品名称Anti-Pinin抗体
    参阅全部 Pinin 一抗
  • 描述
    兔多克隆抗体to Pinin
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow, Dog
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 400 - 500 of Human Pinin.

    (Peptide available as ab89383.)

  • 阳性对照
    • This antibody gave a positive signal in Human Lung and Placenta tissue lysates.

性能

应用

Our Abpromise guarantee covers the use of ab70605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 87 kDa (predicted molecular weight: 81 kDa).

靶标

  • 功能Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
  • 组织特异性Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
  • 序列相似性Belongs to the pinin family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
    • Desmosome-associated protein antibody
    • Domain-rich serine protein antibody
    • DRS antibody
    • DRS protein antibody
    • DRSP antibody
    • Melanoma metastasis clone A protein antibody
    • MEMA antibody
    • Nuclear protein SDK3 antibody
    • Pinin antibody
    • PININ_HUMAN antibody
    • PNN antibody
    • SR like protein antibody
    • SR-like protein antibody
    see all

Anti-Pinin antibody 图像

  • All lanes : Anti-Pinin antibody (ab70605) at 1 µg/ml

    Lane 1 : Human placenta tissue lysate - total protein (ab29745)
    Lane 2 : Lung (Human) Tissue Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 81 kDa
    Observed band size : 87 kDa (why is the actual band size different from the predicted?)


    Exposure time : 8 minutes

Anti-Pinin antibody (ab70605)参考文献

ab70605 has not yet been referenced specifically in any publications.

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