Anti-PIM2抗体[CHU61B] (ab107102)

概述

  • 产品名称Anti-PIM2抗体[CHU61B]
    参阅全部 PIM2 一抗
  • 描述
    大鼠单克隆抗体[CHU61B] to PIM2
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Immunogen information is not availble

  • 阳性对照
    • Human seminoma.

性能

应用

Our Abpromise guarantee covers the use of ab107102 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/2. Predicted molecular weight: 34 kDa.
IHC-P 1/2.

靶标

  • 功能Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade; this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
  • 组织特异性Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated.
  • Information by UniProt
  • 数据库链接
  • 别名
    • OTTHUMP00000025825 antibody
    • Pim 2 oncogene antibody
    • Pim 2h antibody
    • Pim-2h antibody
    • PIM2 antibody
    • PIM2 Oncogene antibody
    • PIM2_HUMAN antibody
    • Pim2h antibody
    • Proto Oncogene PIM2 antibody
    • Proto-oncogene Pim-2 (serine threonine kinase) antibody
    • Serine/threonine kinase PIM2 antibody
    • Serine/threonine-protein kinase Pim-2 antibody
    see all

Anti-PIM2 antibody [CHU61B] 图像

  • ab107102, at 1/2 dilution, staining PIM2 in Human seminoma by Immunohistochemistry.

Anti-PIM2 antibody [CHU61B] (ab107102)参考文献

ab107102 has not yet been referenced specifically in any publications.

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