概述

  • 产品名称Anti-PILRA抗体
  • 描述
    兔多克隆抗体to PILRA
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within N-terminal amino acids 51-100 (IPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFL N) of Human PILRA isoform 3 (NP_840057). Note: this aminoacid sequence is identical in all 4 isoforms of human PILRA.

  • 阳性对照
    • HepG2 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG

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应用

Our Abpromise guarantee covers the use of ab105605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 34 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
  • 组织特异性Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors.
  • 序列相似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. PTPN6 seems to bind predominantly to the first ITIM motif.
  • 翻译后修饰According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.
    Phosphorylated on tyrosine residues.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cell surface receptor FDF03 antibody
    • FDF03 antibody
    • Inhibitory receptor PILR-alpha antibody
    • paired immunoglobulin-like receptor alpha antibody
    • Paired immunoglobulin-like type 2 receptor alpha antibody
    • PILRA antibody
    • PILRA_HUMAN antibody
    see all

Anti-PILRA antibody 图像

  • Anti-PILRA antibody (ab105605) at 0.5 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 34 kDa

Anti-PILRA antibody (ab105605)参考文献

ab105605 has not yet been referenced specifically in any publications.

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