概述

  • 产品名称
  • 描述
    兔多克隆抗体to PIK3R5
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide is a 15mer between amino acids 400 and 450 of human PI3KR5, conjugated to KLH.

  • 阳性对照
    • K562 cell lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 纯化说明
    ab62792 was purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab62792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Detects a band of approximately 97 kDa (predicted molecular weight: 97 kDa).
ELISA 1/1000.

靶标

  • 功能
    Regulatory subunit of the PI3K gamma complex.
  • 组织特异性
    Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
  • 疾病相关
    Note=Defects in PIK3R5 may be a cause of autosomal recessive ataxia with oculomotor apraxia (AOA). A PIK3R5 mutation segregates with the disease phenotype in a family affected by gait ataxia, cerebellar dysarthric speech, and impaired ocular movement. Additional features include reduced or absent tendon reflexes, severe cerebellar atrophy, marked vermal atrophy, moderately severe axonal sensory polyneuropathy with absent sensory nerve action potential in the lower extremities, and persistently elevated alpha-fetoprotein levels.
  • 结构域
    The heterodimerization region allows the binding to the catalytic subunit.
  • 细胞定位
    Nucleus. Cytoplasm. Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5-bisphosphate 3-kinase regulatory subunit antibody
    • F730038I15Rik antibody
    • FOAP 2 antibody
    • FOAP2 antibody
    • OTTHUMP00000135339 antibody
    • p101 antibody
    • P101 PI3K antibody
    • p101-PI3K antibody
    • Phosphatidylinositol 4 antibody
    • Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit antibody
    • Phosphoinositide 3 kinase, regulatory subunit 5 antibody
    • Phosphoinositide 3 kinase, regulatory subunit 5, p101 antibody
    • Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101 antibody
    • Phosphoinositide 3-kinase regulatory subunit 5 antibody
    • PI3 kinase p101 subunit antibody
    • PI3 kinase regulatory subunit 5 antibody
    • PI3-kinase p101 subunit antibody
    • PI3-kinase regulatory subunit 5 antibody
    • PI3R5_HUMAN antibody
    • PIK3 R5 antibody
    • PIK3R5 antibody
    • Protein FOAP 2 antibody
    • Protein FOAP-2 antibody
    • PtdIns 3 kinase p101 antibody
    • PtdIns 3 kinase regulatory subunit antibody
    • PtdIns-3-kinase p101 antibody
    • PtdIns-3-kinase regulatory subunit antibody
    see all

图片

  • Anti-PIK3R5 antibody (ab62792) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 97 kDa
    Observed band size : 97 kDa
    Additional bands at : 55 kDa,75 kDa. We are unsure as to the identity of these extra bands.

实验方案

文献

This product has been referenced in:
  • Wilson LS  et al. A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. J Biol Chem 286:16285-96 (2011). WB ; Human . Read more (PubMed: 21393242) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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