概述

  • 产品名称Anti-PIGV抗体
    参阅全部 PIGV 一抗
  • 描述
    兔多克隆抗体to PIGV
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 51-100 (FVDQLVEGLL GGLSHWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLVGTE) of Human PIGV (NP_060307)

  • 阳性对照
    • Jurkat cell lysate, Human kidney tissue

性能

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应用

Our Abpromise guarantee covers the use of ab105697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 4 - 8 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 5 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.
  • 通路Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
  • 疾病相关Defects in PIGV are the cause of hyperphosphatasia with mental retardation (HPMR) [MIM:239300]. It is a syndrome characterized by elevated serum alkaline phosphatase, severe mental retardation, seizures, hypotonia, facial dysmorphism, and hypoplastic terminal phalanges.
  • 序列相似性Belongs to the PIGV family.
  • 翻译后修饰Not N-glycosylated.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GPI mannosyltransferase 2 antibody
    • GPI mannosyltransferase II antibody
    • GPI MT II antibody
    • GPI-MT-II antibody
    • Phosphatidylinositol glycan biosynthesis class V protein antibody
    • Phosphatidylinositol-glycan biosynthesis class V protein antibody
    • PIG-V antibody
    • Pigv antibody
    • PIGV_HUMAN antibody
    see all

Anti-PIGV antibody 图像

  • Paraffin embedded Human kidney tissue labelled with ab105697 at 8 µg/ml. Positively labelled epithelial cells of the renal tubule are indicated with arrows.
  • All lanes : Anti-PIGV antibody (ab105697) at 5 µg/ml

    Lane 1 : Molecular weight marker
    Lane 2 : Jurkat cell lysate at 10 µg


    Predicted band size : 56 kDa

Anti-PIGV antibody (ab105697)参考文献

ab105697 has not yet been referenced specifically in any publications.

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