The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
功能Type I collagen is a member of group I collagen (fibrillar forming collagen).
组织特异性Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
疾病相关Caffey disease Ehlers-Danlos syndrome 1 Ehlers-Danlos syndrome 7A Osteogenesis imperfecta 1 Osteogenesis imperfecta 2 Osteogenesis imperfecta 3 Osteogenesis imperfecta 4 Osteoporosis A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF.
序列相似性Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. Contains 1 VWFC domain.
结构域The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
翻译后修饰Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains. O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
细胞定位Secreted > extracellular space > extracellular matrix.