6xhis tagged fusion protein:
EKMELLDQKH VQDIVFQLQR FVSTMSKYYN DCYAVLQDAD VFPIEVDLAH TTLAYGPNQG SFTDGEEEDE EEEDGAAREV SKDACGATGP TDKGGSWCDS
, corresponding to C terminal amino acids 317-416 of Mouse PICK1.
RIPA lysates from rat brain microsomal preparation.
Shipped at 4°C. Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Preservative: 0.05% Sodium Azide
Constituents: 5mg/ml BSA, 0.15M Sodium Chloride, 50mM Glycine, 0.2mM Tris, 0.1mM EDTA. pH 7.4
Concentration information loading...
Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Predicted molecular weight: 50 kDa.
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
Contains 1 AH domain.
Contains 1 PDZ (DHR) domain.
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
Cytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
Information by UniProt
Anti-PICK1 antibody (ab15001)参考文献
has not yet been referenced specifically in any publications.
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