Anti-PI 4 Kinase type 2 beta抗体(ab99143)

概述

  • 产品名称Anti-PI 4 Kinase type 2 beta抗体
    参阅全部 PI 4 Kinase type 2 beta 一抗
  • 描述
    兔多克隆抗体to PI 4 Kinase type 2 beta
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Goat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Saccharomyces cerevisiae, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 143-192 (IIGVFKPKSE EPYGQLNPKW TKYVHKVCCP CCFGRGCLIP NQGYLSEAGA) of Human PI 4 Kinase type 2 beta (NP_060793).

  • 阳性对照
    • 721_B cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab99143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
    Contains 1 PI3K/PI4K domain.
  • 细胞定位Cytoplasm. Membrane. Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2610042N09Rik antibody
    • 4933409G22Rik antibody
    • FLJ11105 antibody
    • P4K2B_HUMAN antibody
    • Phosphatidylinositol 4 kinase type 2 beta antibody
    • Phosphatidylinositol 4 kinase type II beta antibody
    • Phosphatidylinositol 4-kinase type 2-beta antibody
    • Phosphatidylinositol 4-kinase type II-beta antibody
    • PI4K 2 beta antibody
    • PI4K 2b antibody
    • PI4K II beta antibody
    • PI4K IIb antibody
    • Pi4k2b antibody
    • PI4KII-BETA antibody
    • PI4KIIb antibody
    • PIK42B antibody
    • Type II phosphatidylinositol 4 kinase beta isoform antibody
    see all

Anti-PI 4 Kinase type 2 beta antibody 图像

  • Anti-PI 4 Kinase type 2 beta antibody (ab99143) at 1 µg/ml + 721_B cell lysate at 10 µg

    Predicted band size : 55 kDa

Anti-PI 4 Kinase type 2 beta antibody (ab99143)参考文献

ab99143 has not yet been referenced specifically in any publications.

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