Anti-PI 3 Kinase p85 alpha抗体[U13] (ab250)


  • 产品名称Anti-PI 3 Kinase p85 alpha抗体[U13]
    参阅全部 PI 3 Kinase p85 alpha 一抗
  • 描述
    小鼠单克隆抗体[U13] to PI 3 Kinase p85 alpha
  • 特异性Recognises the SH3 domain of the p85 alpha subunit of bovine PI 3 kinase. This antibody is specific for the p85 alpha isoform and does not bind to the p85 beta isoform (see End et al, J Biol Chem. 1993 May 15;268(14):10066-75).
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Rat, Cow, Human, Monkey
  • 免疫原

    Baculovirus expressed (recombinant) Bovine p85 alpha subunit of PI 3 Kinase.



Our Abpromise guarantee covers the use of ab250 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200.
IP Use at an assay dependent dilution. USE NEAT.


  • 功能Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
  • 组织特异性Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
  • 序列相似性Belongs to the PI3K p85 subunit family.
    Contains 1 Rho-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • 结构域The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
  • 翻译后修饰Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
    Phosphorylated. Dephosphorylated by PTPRJ.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GRB1 antibody
    • p85 alpha antibody
    • p85 antibody
    • P85A_HUMAN antibody
    • Phosphatidylinositol 3 kinase associated p 85 alpha antibody
    • Phosphatidylinositol 3 kinase regulatory 1 antibody
    • Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) antibody
    • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody
    • Phosphatidylinositol 3-kinase regulatory subunit alpha antibody
    • Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) antibody
    • PI3 kinase p85 subunit alpha antibody
    • PI3-kinase regulatory subunit alpha antibody
    • PI3-kinase subunit p85-alpha antibody
    • PI3K antibody
    • PI3K regulatory subunit alpha antibody
    • Pik3r1 antibody
    • PtdIns 3 kinase p85 alpha antibody
    • PtdIns-3-kinase regulatory subunit alpha antibody
    • PtdIns-3-kinase regulatory subunit p85-alpha antibody
    see all

Anti-PI 3 Kinase p85 alpha antibody [U13] (ab250)参考文献

This product has been referenced in:
  • Rabinovsky R  et al. p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol 29:5377-88 (2009). WB ; Human . Read more (PubMed: 19635806) »
  • Salazar L  et al. A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells. Hum Mol Genet 18:1951-61 (2009). WB ; Human . Read more (PubMed: 19286672) »

See all 4 Publications for this product

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