Anti-PI 3 Kinase catalytic subunit alpha抗体(ab87530)

概述

  • 产品名称Anti-PI 3 Kinase catalytic subunit alpha抗体
    参阅全部 PI 3 Kinase catalytic subunit alpha 一抗
  • 描述
    山羊多克隆抗体to PI 3 Kinase catalytic subunit alpha
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Cow, Dog, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    C-HQWLKDKNKGEIYD

    corresponding to internal amino acids 878 - 891 of Human PI 3 Kinase catalytic subunit alpha (NP_006209.2), with a cysteine residue linker

  • 阳性对照
    • Human cerebral cortex

性能

应用

Our Abpromise guarantee covers the use of ab87530 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/128000.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
  • 疾病相关Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500].
    Defects in PIK3CA are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
    Defects in PIK3CA are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
    Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550].
    Defects in PIK3CA are a cause of keratosis seborrheic (KERSEB) [MIM:182000]. A common benign skin tumor. Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance.
  • 序列相似性Belongs to the PI3/PI4-kinase family.
    Contains 1 C2 domain.
    Contains 1 PI3K/PI4K domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha antibody
    • 5-bisphosphate 3-kinase catalytic subunit alpha isoform antibody
    • caPI3K antibody
    • CLOVE antibody
    • CWS5 antibody
    • MCAP antibody
    • MCM antibody
    • MCMTC antibody
    • MGC142161 antibody
    • MGC142163 antibody
    • p110 alpha antibody
    • p110alpha antibody
    • Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody
    • Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha antibody
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody
    • Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha antibody
    • Phosphatidylinositol-4 antibody
    • Phosphoinositide 3 kinase catalytic alpha polypeptide antibody
    • PI3 kinase p110 subunit alpha antibody
    • PI3-kinase subunit alpha antibody
    • PI3K antibody
    • PI3K-alpha antibody
    • PI3KC A antibody
    • PIK3C A antibody
    • Pik3ca antibody
    • PK3CA antibody
    • PK3CA_HUMAN antibody
    • PtdIns 3 kinase p110 antibody
    • PtdIns-3-kinase subunit alpha antibody
    • PtdIns-3-kinase subunit p110-alpha antibody
    • Serine/threonine protein kinase PIK3CA antibody
    see all

Anti-PI 3 Kinase catalytic subunit alpha antibody 图像

  • ab87530, at 2.0 ug/ml, staining PI 3 Kinase catalytic subunit alpha in paraffin-embedded Human cerebellar cortex tissue.

Anti-PI 3 Kinase catalytic subunit alpha antibody (ab87530)参考文献

ab87530 has not yet been referenced specifically in any publications.

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