Anti-PHYH抗体(ab118195)
Key features and details
- Rabbit polyclonal to PHYH
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-PHYH抗体 -
描述
兔多克隆抗体to PHYH -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant fragment, corresponding to amino acids 34-321 of Human PHYH (BC029512).
-
阳性对照
- Human fetal kidney and liver lysates; Human breast carcinoma tissue
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Lyophilized:Reconstitute in 200µl sterile water -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab118195于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 39 kDa.
|
|
IHC-P |
1/100 - 1/500.
|
说明 |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 39 kDa. |
IHC-P
1/100 - 1/500. |
靶标
-
功能
Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. -
组织特异性
Expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle. -
通路
Lipid metabolism; fatty acid metabolism. -
疾病相关
Defects in PHYH are a cause of Refsum disease (RD) [MIM:266500]. RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentosa, peripheral neuropathy, cerebellar ataxia, and elevated protein levels in the cerebrospinal fluid (CSF). Patients exhibit accumulation of the branched-chain fatty acid, phytanic acid, in blood and tissues. Less constant features are nerve deafness, anosmia, skeletal abnormalities, ichthyosis, cataracts and cardiac impairment. Manifestations of the disease appear in the second or third decade of life. -
序列相似性
Belongs to the PhyH family. -
细胞定位
Peroxisome. - Information by UniProt
-
数据库链接
- Entrez Gene: 5264 Human
- Entrez Gene: 16922 Mouse
- Entrez Gene: 114209 Rat
- Omim: 602026 Human
- SwissProt: O14832 Human
- SwissProt: O35386 Mouse
- SwissProt: P57093 Rat
- Unigene: 498732 Human
see all -
别名
- LN1 antibody
- LNAP1 antibody
- LNAP1, mouse, homolog of antibody
see all
图片
-
All lanes : Anti-PHYH antibody (ab118195) at 1/500 dilution
Lane 1 : Human fetal kidney lysate
Lane 2 : Human fetal liver lysate
Predicted band size: 39 kDa -
ab118195, at 1/100 dilution, staining PHYH in formalin-fixed, paraffin-embedded Human breast carcinoma tissue showing cytoplasmic staining, by Immunohistochemistry.
数据表及文件
-
SDS download
-
Datasheet download
文献 (0)
ab118195 尚未被引用在任何文献中。